Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
| Reactant | HCID 69160385 | HCID 69160385 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | HCID 69313869 | HCID 69313869 | — |
Reaction Steps
A mixture of amide from step 1 (1 eq), ethyl 2-(trans)-(4-bromophenyl)cyclopropanecarboxylate from EXAMPLE 1, step 1 (1 eq), Na2CO3 (3.5 eq.; 2M in H2O), Pd(PPh3)4 (0.05 eq) in n-propanol (0.1M) was stirred at 80° C. for 3 h. The mixture was cooled to rt, quenched with brine and diluted with EtOAc. The organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was triturated in ether/MeOH, isolated by filtration and washed with ether to afford the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07238706B2 |
|---|
| Source dataset | uspto-grants-2007_07 |
|---|
| ORD ID | ord-a77fa842273540f483d87696336e7022 |
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| Source note | uspto-grants-2007_07 |
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