HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294401Generated: October 25, 2026
Potassium Carbonate → 1-Benzyl-4-(4-nitrophenyl)-[1,4]diazepane
https://huagongshe.com/reaction/1294401
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 1-Benzyl-1,4-diazepane | HCID 228365 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzyl-4-(4-nitrophenyl)-[1,4]diazepane | HCID 13007957 | — |
Reaction Steps
Fluoronitrobenzene (3.09 g, 21.9 mmol) is dissolved in water (14 ml), and then potassium carbonate (3.64 g, 26.28 mmol) and 1-benzylhomopiperazine (5 g, 26.28 mmol) are added. The medium is heated at 90° C. for 4 h 20 min and then cooled to room temperature. The precipitate formed is filtered, and a yellow solid is obtained. 6.30 g (92.5%) of product are recovered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07241317B2 |
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| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-9ac02f125e9f40809ba6a88309620c1f |
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| Source note | uspto-grants-2007_07 |
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