Diclofenac → HCID 86595983, compound

HRID 1294406Notes

Reaction equation

HRID 1294406 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:13]([Cl:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.[OH-].[Na+].O.O.O.O.O.O.[Cl-].[Sr+2:29].[Cl-]>O.C(O)C.O>[Sr:29].[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1

Participants

6

Reactant 3

HCID 3033DiclofenacHCID 14798Sodium HydroxideHCID 610186810025-70-4

Product 1

HCID 86595983HCID 86595983, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 19096565Water ethanolSolvent

Procedure

Diclofenac (0.35 g, 1.18 mmol) was dissolved in water/ethanol (30 ml, 50:50 (volume)) containing sodium hydroxide (24 mg, 0.59 mmol). A solution of strontium chloride hexahydrate (0.16 g, 0.59 mmol) in water (3 ml) was added. The mixture was stirred for 20 minutes, and the title compound was isolated by filtration and dried. Yield 0.122 g (15%).

Sources & evidence

ORD record
ord-8f1fc0fe9f5f4b8888d0bfc4da59b95b
Source dataset
uspto-grants-2007_07
Patent number
US07241460B2

Reaction notes

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