Azane;hydrate → O-(4-cyano-2-ethoxybenzyloxy)hydroxyamine
Reaction equation
Cl.[C:2]([C:4]1[CH:12]=[CH:11][C:7]([CH2:8][O:9]N)=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=1)#[N:3].[OH2:16].[NH3:17]>>[C:2]([C:4]1[CH:12]=[CH:11][C:7]([CH2:8][O:9][O:16][NH2:17])=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=1)#[N:3]Participants
3
Procedure
The O-(4-cyano-2-ethoxybenzyl)hydroxyamine hydrochloride (19) and ammonia water were mixed, then, extracted with ethyl acetate to obtain O-(4-cyano-2-ethoxybenzyl)hydroxyamine (18) (80 mg, 0.42 mmol). This was dissolved in acetonitrile (12 ml), then, several drops of 85% phosphoric acid aqueous solution were dropped on this, and the produced white solid was filtrated by filtration under reduced pressure. The filtrated substance was washed with acetonitrile, then, the filtrated substance was recovered and dried by a vacuum pump to obtain 60 mg of a while solid.
Workup
- extractionextracted with ethyl acetate
Sources & evidence
- ORD record
- ord-b8ac6282859a4fbf923ef2bb1378f113
- Source dataset
- uspto-grants-2007_07
- Patent number
- US07241625B2
Reaction notes
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