HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium hypochlorite → 6-Chloro-8-difluoromethoxychroman-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium hypochlorite | HCID 24504 | — |
| Reactant | 8-Difluoromethoxychroman-4-one | HCID 22708346 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Acetic acid--water (1/1) | HCID 21899381 | — |
| Product | 6-Chloro-8-difluoromethoxychroman-4-one | HCID 22708349 | 93% |
Reaction Steps
To a solution of calcium hypochlorite (29.4 g, 137.8 mmol) in water:acetic acid (125:9.5) was added a solution of 8-difluoromethoxychroman-4-one (7.4 g, 34.6 mmol, see step (iv) above) in acetonitrile (20 mL), whereafter the reaction mixture was stirred overnight. The mixture was diluted with water and extracted with ether (3×) and with EtOAc (1×). The combined organic layers were washed with water (3×), dried (Na2SO4) and evaporated, yielding 8.0 g (93%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241757B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-cdf94016d21d4f8bbccb56f6417e469e |
| Source note | uspto-grants-2007_07 |