2-Chloro-5-fluoropyridine → 2-Chloro-5-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-pyridine

HRID 1294489Notes

Reaction equation

HRID 1294489 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20](F)=[CH:19][N:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:11]=[C:12]2[CH3:15])=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 27828012-Chloro-5-fluoropyridineHCID 178432693HCID 178432693, compound

Product 1

HCID 111864802-Chloro-5-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-pyridine

Procedure

The title compound, MS: m/e=328.1 (M+), was prepared in accordance with the general method of example 1 from 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole and 2-chloro-5-fluoro-pyridine.

Sources & evidence

ORD record
ord-45b9bc812f184852922faf60a1b58d13
Source dataset
uspto-grants-2007_07
Patent number
US07241760B2

Reaction notes

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