2-Chloro-4-methylpyrimidine → HCID 11438270, compound

HRID 1294492Notes

Reaction equation

HRID 1294492 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:17]1[N:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:17]3[N:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 116296072-Chloro-4-methylpyrimidineHCID 178432693HCID 178432693, compound

Product 1

HCID 11438270HCID 11438270, compound

Procedure

The title compound, MS: m/e=309.1 (M+H+), was prepared in accordance with the general method of example 1 from 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole and 2-chloro-4-methyl-pyrimidine (prepared according to Harden, D. B.; Makrosz, M. J.; Strekowski, L.; J. Org. Chem. 1988, 53, 4137).

Sources & evidence

ORD record
ord-80027cf0e0274bae9f041b57198b8584
Source dataset
uspto-grants-2007_07
Patent number
US07241760B2

Reaction notes

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