2-Fluoro-6-(trifluoromethyl)pyridine → 2-[4-(3-Chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-6-trifluoromethyl-pyridine

HRID 1294510Notes

Reaction equation

HRID 1294510 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1.F[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27365012-Fluoro-6-(trifluoromethyl)pyridineHCID 178432693HCID 178432693, compound

Product 1

HCID 117728462-[4-(3-Chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-6-trifluoromethyl-pyridine

Procedure

The title compound, MS: m/e=362.2 (M+), was prepared in accordance with the general method of example 1 from 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole and 2-fluoro-6-trifluoromethyl-pyridine.

Sources & evidence

ORD record
ord-847ed0eb0fd144d587bdde664050248c
Source dataset
uspto-grants-2007_07
Patent number
US07241760B2

Reaction notes

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