Isopropylamine → HCID 68549585, compound

HRID 1294555Notes

Reaction equation

HRID 1294555 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]2[NH:10]C(=O)O[C:7](=[O:12])[C:6]=2[CH:13]=1.[CH:15]([NH2:18])([CH3:17])[CH3:16]>N1C=CC=CC=1>[NH2:10][C:5]1[C:4]([CH3:14])=[CH:3][C:2]([Br:1])=[CH:13][C:6]=1[C:7]([NH:18][CH:15]([CH3:17])[CH3:16])=[O:12]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 22493297HCID 22493297, compound

Product 1

HCID 68549585HCID 68549585, compoundYield 118.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a suspension of the benzoxazinedione of Step E, (4.0 g, 15.56 mmol) in pyridine (20 mL) was added isopropylamine (1.2 g, 20.23 mmol) and the reaction was heated to reflux for 2 hours. The reaction was then cooled, concentrated from toluene on a rotary evaporator and then dried under vacuum to afford a solid (5.01 g).

Workup

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe reaction was then cooled
  4. concentrationconcentrated from toluene on a rotary evaporator
  5. customdried under vacuum

Sources & evidence

ORD record
ord-5a207e6f168f4defb8679851020d7b80
Source dataset
uspto-grants-2007_07
Patent number
US07241767B2

Reaction notes

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