Diisopropylethylamine → HCID 23106209, compound

Participants

Reaction Steps

5 g (21.9 mmol) 2,4-dichloro-5-trifluoromethyl-pyrimidine are dissolved in 50 ml 1,4-dioxane and combined with 5.50 g (21.9 mmol) 4-amino-3-methoxybenzoic acid-propylamide hydrochloride (Journal of Pharmaceutical Sciences 1989, 78(10), 829-32). 7.50 ml (43.8 mmol) ethyldiisopropylamine are added to this reaction mixture and it is stirred for 2 days at ambient temperature. Then the reaction mixture is diluted with 250 ml of ethyl acetate and washed first of all with 300 ml aqueous 10% KHSO4 solution, then with 300 ml saturated, aqueous NaCl solution. The organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

Provenance & Evidence