反应详情

温度

0 °C

676.3 mg (17.8 mmol) lithium aluminium hydride are placed in 65 ml diethyl ether under an N2 atmosphere and cooled to 0° C. 2.01 g (11.9 mmol) methyl 2-amino-6-fluoro-benzoate, dissolved in 65 ml diethyl ether, are slowly added dropwise thereto and the mixture is stirred for 2 h at 0° C. Then the reaction mixture is combined dropwise at 0° C. with 100 ml dist. H2O. The aqueous phase is extracted twice with 100 ml diethyl ether. The combined organic phases are washed once with 100 ml of a saturated, aqueous NaCl solution, dried with MgSO4 and the solvent is eliminated in vacuo.

1. additionare slowly added dropwise
2. customis combined dropwise at 0° C. with 100 ml dist
3. extractionThe aqueous phase is extracted twice with 100 ml diethyl ether
4. washThe combined organic phases are washed once with 100 ml of a saturated, aqueous NaCl solution
5. dry with materialdried with MgSO4