2-(2-nitrophenyl)-1H-imidazole → 2-(1H-Imidazol-2-yl)aniline

HRID 1294570Notes

Reaction equation

HRID 1294570 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:11][CH:12]=[CH:13][N:14]=1)([O-])=O>[Pd].[Ni]>[NH:11]1[CH:12]=[CH:13][N:14]=[C:10]1[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[NH2:1]

Participants

4

Reactant 1

HCID 8210062-(2-nitrophenyl)-1H-imidazole

Product 1

HCID 156205002-(1H-Imidazol-2-yl)aniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 23938PalladiumCatalyst

Procedure

By catalytic hydrogenation, using palladium on charcoal or Raney Nickel as catalyst, 2-(2-nitro-phenyl)-1H-imidazole, which is commercially obtainable, is converted into 2-(1H-imidazol-2-yl)-phenylaamine (U.S. Pat. No. 6,376,664).

Sources & evidence

ORD record
ord-9fd4041c4a4846e3988b66266169cd41
Source dataset
uspto-grants-2007_07
Patent number
US07241769B2

Reaction notes

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