HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → HCID 58906439, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | tert-Butyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylate | HCID 22135564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58906439 | HCID 58906439 | — |
Reaction Steps
Epoxide (32) (46 g, 216 mmol) was dissolved in dioxane (300 ml). Benzyl methylamine (75 ml, 583 mmol) was added and the mixture was stirred at reflux for 90 h. TLC analysis revealed complete conversion. The mixture was evaporated to dryness. The excess of benzyl methylamine was removed by evaporation in vacuo (0.05 mbar, 80° C.). Yield: 69.3 g of aminoalcohol (35) (96%) as an orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241770B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-43ac2997145a4bbd9584ee7e394dccb7 |
| Source note | uspto-grants-2007_07 |