Aminoacetaldehyde dimethyl acetal → HCID 178495888, compound

Participants

Reaction Steps

A mixture of 3.16 g of 1H-3-benzazepin-2-amine, 4.17 g of 2,2-dimethoxyethanamine and 50 ml of methanol was stirred for 16 hours at reflux temperature. The reaction mixture was evaporated and the residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 95:5). The eluent of the desired fraction was evaporated and the residue was stirred in hexane. The precipitate was filtered off, yielding 4.9 g (100% ) of N-(2,2-dimethoxyethyl)-1H-3-benzazepin-2-amine (interm. 28).

Provenance & Evidence