Acetic Anhydride → HCID 23248656, compound

HRID 1294637Notes

Reaction equation

HRID 1294637 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[O:10].[C:18](OC(=O)C)(=[O:20])[CH3:19]>C1(C)C=CC=CC=1>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:18](=[O:20])[CH3:19])=[C:3]([C:9](=[O:10])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 182478(2-Amino-5-bromophenyl)(3-chlorophenyl)methanone

Product 1

HCID 23248656HCID 23248656, compoundYield 120.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of intermediate 2 (0.328 mol) and acetic acid anhydride (0.656 mol) in toluene (1200 ml) was stirred and refluxed for one night. The mixture was evaporated and the product was used without further purification, yielding 139 g (quant.) of N-[4-bromo-2-(3-chlorobenzoyl)phenyl]-acetamide (intermediate 3).

Workup

  1. temperaturerefluxed for one night
  2. customThe mixture was evaporated
  3. customthe product was used without further purification

Sources & evidence

ORD record
ord-afda9417be2f478eaa7efd83f5d44a02
Source dataset
uspto-grants-2007_07
Patent number
US07241777B2

Reaction notes

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