Methanol → HCID 11340294, compound

Participants

Reaction Steps

A mixture of intermediate 7 (0.94 mol) in HCl 3N (5 ml) was stirred at reflux overnight, cooled at room temperature and poured out into ice water. DCM and methanol (little quantity) were added. The organic layer was basified by K2CO3, separated, dried over MgSO4, filtered, and the solvent was evaporated, yielding 0.44 g of 4-[[5-[[4-(3-chlorophenyl)-1,2-dihydro-2-oxo-6-quinolinyl]hydroxymethyl]-1H-imidazol-1-yl]methyl]-benzonitrile (compound 1).

Provenance & Evidence