Hydrochloric Acid → HCID 69520612, compound

Participants

Reaction Steps

The product of Example 6A (230 mg, 0.73 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol) to provide the title compound as a solid (106 mg, yield, 42%). 1H NMR (MeOH-d4, 300 MHz) δ 1.79–2.21 (m, 3H), 30 2.32–2.40 (m, 1H), 2.56 (m, 1H), 3.30–3.48 (m, 5H), 3.80 (m, 1H), 4.90 (m, 6.62(dt, J=10.5, 2.4 Hz, 1H), 6.73(dd, J=8.1, 2.3Hz, 1H), 6.78 (tdd, J=8.5, 2.3, 1.0 Hz, 1H), 7.03 (s, 4H), 7.30 (td, J=8.2, 6.7Hz, 1H) ppm. MS (DCl/NH3) m/z 314 (M+H)+. Anal. calculated for C19H20FNO2.1.0HCl: C, 65.23; H, 6.05; N, 4.00. Found: C, 64.96; H, 6.17; N, 3.96.

Provenance & Evidence