Hydrochloric Acid → HCID 69519336, compound

Participants

Reaction Steps

The product of Example 7A (210 mg, 0.68 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol) to provide the title compound as a solid (140 mg, yield, 59%). 1H NMR (MeOH-d4, 300 MHz) δ 1.73–2.19 (m, 3H), 2.21–2.40 (m, 1H), 2.41–2.56 (m, 1H), 3.30–3.50 (m, 5H), 3.69–3.83 (m, 1H), 4.80 (m, 1H), 6.59–7.04 (m, 8H) ppm. MS (DCl/NH3) m/z 312 (M+H)+. Anal. calculated for C19H21NO3.1.0HCl: C, 65.61; H, 6.37; N, 4.03. Found: C, 65.31; H, 6.32; N, 3.86.

Provenance & Evidence