Hydrochloric Acid → HCID 69519882, compound

Participants

Reaction Steps

The product of Example 10A (200 mg, 0.61 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol) to provide the title compound as a solid (140 mg, yield, 63%). 1H NMR (MeOH-d4, 300 MHz) δ 1.75–2.19 (m, 3H), 2.19–2.38 (m, 1H), 2.43–2.56 (m, 1H), 3.20–3.50 (m, 5H), 3.66–3.84 (m, 1H), 6.76 (d, J=8.9 Hz, 2H), 6.90 (d, J=8.9 Hz, 2H), 7.19 (d, J=8.8 Hz, 2H), 7.22 (d, J=8.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 328 (M+H)+. Anal. calculated for C19H21NO2S.1.0HCl.0.8H2O: C, 60.32; H, 6.29; N, 3.70. Found: C, 60.34; H, 6.N, 3.32.

Provenance & Evidence