Methanol → HCID 69520284, compound

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Reaction Steps

The product of Example 13A (74 mg, 0.2 mmol) in ethyl acetate:MeOH (5 mL, 10:1) was treated with fumaric acid (Aldrich, 21 mg, 0.2 mmol). The title compound was obtained as solid (90 mg, yield, 95%): 1H NMR (MeOH-d4, 300 MHz) δ 1.75–2.19 (m, 3H), 2.19–2.38 (m, 1H), 2.43–2.56 (m, 1H), 3.20–3.50 (m, 5H), 3.66–3.84 (m, 1H), 4.80 (m, 1H), 6.76 (d, J=8.9 Hz, 2H), 6.90 (d, J=8.9 Hz, 2H), 7.19 (d, J=8.8 Hz, 2H), 7.22 (d, J=8.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 70 (M+H)+. Anal. Calculated for C22H27NO2S.1.0C4H4O4.0.4H2O: C, 63.37; H, 6.50; N, 2.84 63.57; H, 6.20; N, 2.80.

Provenance & Evidence