Hydrochloric Acid → HCID 69519169, compound

Participants

Reaction Steps

The product of Example 14A (3.7 g, 11.2 mmol) in ethyl acetate (50 mL) was treated with 4M HCl in 1,4-dioxane (5 mL, 20 mmol). The title compound was obtained as a solid (4.0 g, yield, 98%). 1H NMR (MeOH-d4, 300 MHz) δ 1.80–2.20 (m, 3H), 2.30–2.40 (m, 1H), 2.50 (m, 1H), 3.30–3.48 (m, 5H), 3.76 (m, 1H), 4.92 (m, 1H), 6.80 (d, J=9.1 Hz, 2H), 7.61 (d, J=8.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 330 (M+H)+. Anal. calculated for C13H16INO.1.0HCl: C, 42.70; H, 4.69; N, 3.83. Found: C, 42.72; H, 4.61; N, 3.65.

Provenance & Evidence