Hydrochloric Acid → HCID 69520371, compound

Participants

Reaction Steps

The product of Example 20A (170 mg, 0.53 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol). The title compound was obtained as solid (110 mg, yield, 58%). 1H NMR (MeOH-d4, 300 MHz) δ 1.85–1.95 (m, 1H), 1.97–2.08 (m, 1H), 2.10–2.18 (m, 1H), 2.25–2.40 (m, 1H), 2.52–2.58 (m, 1H), 3.30–3.50 (m, 5H), 3.78–3.85(m, 1H), 4.92 (m, 1H), 7.00 (d, J=9.1 Hz, 2H), 7.50 (t, J=7.8 Hz, 2H), 7.57 (t, J=7.1 Hz, 1H), 7.63 (d, J=9.0 Hz, 2H), 7.92 (d, J=7.5 Hz, 2H) ppm. MS (DCl/NH3) m/z 323 (M+H)+. Anal. Calculated for C20H22N2O2.1.0HCl: C, 66.94; H, 6.46; N, 7.81. Found: C, 66.73; H, 6.59; N, 7.64.

Provenance & Evidence