Cyclohexylamine → HCID 11185677, compound

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Reaction Steps

The product of Example 21A (281 mg, 1.0 mmol) was treated with cyclohexylamine (Aldrich, 150 mg, 1.5 mmol) according to the procedure of Example 17A. The title compound was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:2, Rf. 0.10) as oil (130 mg, yield, 43%). 1H NMR (MeOH-d4, 300 MHz) δ 1.06–1.45 (m, 6H), 1.60–1.90 (m, 5H), 1.93–2.05 (m, 3H), 2.18–2.37 (m, 2H), 3.05–3.28 (m, 5H), 4.30–4.40 (m, 1H), 6.65 (d, J=8.8 Hz, 2H), 6.74 (d, J=9.2 Hz, 2H) ppm. MS (DCl/NH3) m/z 301 (M+H)+.

Provenance & Evidence