Hydrochloric Acid → HCID 69518634, compound

Participants

Reaction Steps

The product of Example 23A (42 mg, 0.11 mmol) in ethyl acetate (3 mL) was treated with 4M HCl in 1,4-dioxane (0.2 mL, 0.8 mmol) at ambient temperature for 10 hours. The title compound was obtained as a solid (22 mg, yield, 40%). 1H NMR (MeOH-d4, 300 MHz) δ 1.87–2.23(m, 3H), 2.30–2.40 (m, 1H), 2.55–2.64 (m, 1H 3.30–3.50 (m, 5H), 3.85–3.92 (m, 1H), 5.05 (m, 1H), 7.23 (d, J=4.1 Hz, 2H), 7.30 (d, J=8.8 Hz, 2H), 7.52 (d, J=3.7Hz, 2H), 7.60 (d, J=8.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 385 (M+H)+. Anal. Calculated for C19H20N4OS2.2HCl.2H2O: C, 46.25; H 5.31; N, 11.35. Found: C, 46.41; H, 5.06; N, 11.09.

Provenance & Evidence