Hydrochloric Acid → HCID 69520874, compound

Participants

Reaction Steps

The product of Example 24A (70 mg, 0.14 mmol) in ethyl acetate (3 mL) was treated with 4M HCl in 1,4-dioxane (0.2 mL, 0.8 mmol) at ambient temperature for 10 hours. The title compound was obtained as a solid (42 mg, yield, 53%). 1H NMR (MeOH-d4, 300 MHz) δ 1.85–2.25(m, 3H), 2.30–2.40 (m, 1H), 3.17–3.44 (m, 6H), 3.60–3.68 (m, 1H), 4.61 (m, 1H), 6.56–6.68 (m, 4H), 7.26–7.44 (m, 5H), 7.61–7.67 (m, 2H), 7.84–7.97 (m, 3H) ppm. MS (DCl/NH3) m/z 483 (M+H)+. Anal. Calculated for C29H26N2OS2.HCl.1.5H2O: C, 63.78; H 5.54; N, 5.13. Found: C, 63.76; H, 5.65 ; 4.84.

Provenance & Evidence