Hydrochloric Acid → HCID 69520085, compound

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Reaction Steps

The product of Example 27C (120 mg, 0.45 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2 mmol). The title compound was obtained as a solid (120 mg, yield, 80%). 1H NMR (MeOH-d4, 300 MHz) δ 1.85–2.18 (m, 1H), 2.30–2.45 (m, 1H), 2.56–2.64 (m, 1H), 3.35–3.50 (m, 5H), 3.85–3.9(m, 1H), 5.45 (m, 1H), 7.18–7.26 (m, 2H), 7.28–7.36 (m, 1H), 7.45–7.51 (m, 2H), 7.52 (s, 2H) ppm. MS (DCl/NH3) m/z 265 (M+H)+. Anal. Calculated for C20H22N2O2.2.0HCl: C, 55.14; H, 5.72; N, 11.35. Found: C, 55.03; H, 5.59; N, 11.64.

Provenance & Evidence