Hydrochloric Acid → HCID 69520839, compound

Participants

Reaction Steps

The product of Example 30A (1.46 g, 4.9 mmol) in ethyl acetate (20 mL) was treated with 4M HCl in 1,4-dioxane (5 mL, 20 mmol). The title compound was obtained as a solid (1.40 g, yield, 77%). 1H NMR (MeOH-d4, 300 MHz) δ 1.90–2.00 (m, 1H), 2.05–2.15 (m, 2H), 2.35–2.45 (m, 2H), 3.15 (ddd, J=12.9, 5.1, 2.4 Hz, 1H) 3.30–3.50 (m, 4H), 3.80 (ddd, J=12.9, 9.5, 2.7 Hz, 1H), 3.95–4.10 (m, 1H), 6.85–7.00 (m, 6H), 7.04 (tt, J=8.4, 1.0 Hz, 1H), 7.26–7.32 (m, 2H) ppm. MS (DCl/NH3) m/z 295 (M+H)+. Anal. Calculated for C19H22N2O.2.0HCl: C, 62.13; H, 6.59; N, 7.63. Found: C, 62.01; H, 6.53; N, 7.49.

Provenance & Evidence