Hydrochloric Acid → HCID 69520191, compound

Participants

Reaction Steps

The product of Example 32A (200 mg, 0.65 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in dioxane (0.5 mL). The title compound was obtained as a solid (180 mg, yield, 73%). 1H NMR (MeOH-d4, 300 MHz) δ 1.96–2.17 (m, 3H), 2.31 (s, 3H), 2.34–2.41 (m, 2H), 3.26–3.54 (m, 5H), 3.81 (ddd, J=12.9, 9.5, 2.4 Hz, 1H), 4.06–4.13 (m, 1H), 6.85 (dt, J=9.0, 2.7 Hz, 2H), 6.97 (dt, J=9.1, 2.7 Hz, 2H) 7.09–7.17 (m, 4H), ppm. MS (DCl/NH3) m/z 309 (M+H)+. Anal. calculated for C20H24N2O.2.0HCl.1.0H2O: C, 60.15; H, 7.07; N, 7.01. Found: C, 60.34; H, 7.14; N, 6.98.

Provenance & Evidence