Hydrochloric Acid → HCID 69519236, compound

Participants

Reaction Steps

The product of Example 35A (100 mg, 0.30 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL). The title compound was obtained as solid (90 mg, yield, 75%). 1H NMR (MeOH-d4, 300 MHz) δ 1.80–1.92 (m, 1H), 2.00–2.10 (m, 2H), 2.18–2.32 (m, 2H), 3.03 (ddd, J=12.9, 5.1, 2.7 Hz, 1H), 3.28–3.41 (m, 4H), 3.78 (ddd, J=12.9, 9.5, 2.4 Hz, 1H), 3.90–3.96 (m, 1H), 6.49 (dt, J=9.0, 2.7 Hz, 2H), 7.42 (dt, J=9.1, 2.7 Hz, 2H) ppm. MS (DCl/NH3) m/z 329 (M+H)+. Anal. calculated for C13H17IN2.2.0HCl: C, 38.93; H, 4.77; N, 6.98. Found: C, 39.07; H, 4.53; N, 6.80.

Provenance & Evidence