Hydrochloric Acid → HCID 69520278, compound

Participants

Reaction Steps

The product of Example 35C (120 mg, 0.40 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL). The title compound was obtained as a solid (100 mg, yield, 69%). 1H NMR (MeOH-d4, 300 MHz) δ 1.86–2.11 (m, 3H), 2.25–2.41 (m, 2H), 3.16 (ddd, J=12.9, 5.1, 2.5 Hz, 1H), 3.27–3.47 (m, 4H), 3.80 (ddd, J=12.9, 9.5, 2.4 Hz, 1H), 4.00–4.07 (m, 1H), 6.83–6.91 (m, 4H), 7.13–7.33 (m, 5H) ppm. MS (DCl/NH3) m/z 294 (M+H)+. Anal. calculated for C19H23N3.2.4HCl .1.0H2O: 57.20; H, 6.92; N, 10.53. Found: C, 57.25; H, 7.00; N, 10.53.

Provenance & Evidence