Hydrochloric Acid → HCID 69518453, compound

Participants

Reaction Steps

The product of Example 36B (220 mg, 0.71 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL). The title compound was obtained as a solid (180 mg, yield, 73%). 1H NMR (MeOH-d4, 300 MHz) δ 1.84–2.02 (m, 2H), 2.05–2.20 (m, 2H), 2.37–2.52 (m, 1H), 3.14 (ddd, J=17.6, 10.5 2.4 Hz, 1H), 3.24–3.45 (m, 4H), 3.70–3.79 (m, 2H), 6.92 (dt, J=8.9, 3.0 Hz, 2H), 6.97–7.08(m, 2H), 7.13–7.19 (m, 1H), 7.30–7.42 (m, 2H), 7.50 (dt, J=9.0, 3.0 Hz, 2H) ppm. MS (DCl/NH3) m/z 312 (M+H)+. Anal. calculated for C19H21NOS.1.0HCl.0.9H2O: C, 62.67; H, 6.59; N, 3.85Found: C, 62.31; H, 6.31; N, 4.23.

Provenance & Evidence