Hydrochloric Acid → HCID 69520063, compound

Participants

Reaction Steps

The product of Example 37A (210 mg, 0.68 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL). The title compound was obtained as a solid (150 mg, yield, 58%). 1H NMR (MeOH-d4, 300 MHz) δ 1.83–1.99 (m, 2H), 2.03–2.17 (m, 2H), 2.43–2.54 (m, 1H), 3.12 (ddd, J=12.5, 5.4 2.4 Hz, 1H), 3.26–3.46 (m, 4H), 3.58–3.75 (m, 2H), 6.91 (tt, J=7.4, 1.0 Hz, 1H), 7.04 (dt, J=8.8, 2.0 Hz, 2H), 7.09–7.12 (m, 2H), 7.22–7.25 (m, 2H), 7.38 (dt, J=8.8, 2.0 Hz, 2H) ppm. MS (DCl/NH3) m/z 311 (M+H)+. Anal. calculated for C19H22N2S.2.0HCl.1.5H2O: C, 55.47; H, 6.86; N, 6.81. Found: C, 55.72; H, 6.67; N, 6.26.

Provenance & Evidence