Hydrochloric Acid → HCID 69521026, compound

Participants

Reaction Steps

The product of Example 39A (80 mg, 0.19 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.5 mL, 2.0 mmol) in EtOAc (5 mL) at room temperature for 10 h to give the title compound as yellow solid (60 mg, yield, 79%). 1H NMR (MeOH-d4, 300 MHz) δ 1.76–2.20 (m, 3H), 2.21–2.40 (m, 1H), 2.40–2.59 (m, 1H), 3.20–3.48 (m, 6H), 3.70–3.85 (m, 1H), 6.83–7.19 (m, 8H) ppm. MS (DCl/NH3) m/z 426(M+H)+. Anal. Calculated for C19H23N3O2.2.40HCl.0.20H2O.0.50EtOAc: C, 54.76; H, 6.52; N, 9.12. Found: C, 54.50; H, 6.13; N, 8.84.

Provenance & Evidence