Hydrochloric Acid → HCID 69520163, compound

Participants

Reaction Steps

The product of Example 41A (20 mg, 0.05 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.25 mL, 1.0 mmol) in EtOAc (2 mL) at ambient temperature for 1 hour to give the title compound as solid (20.0 mg, yield, 80%). 1H NMR (MeOH-d4, 300 MHz) δ 1.87–2.20 (m, 3H), 2.27–2.47 (m, 1H), 2.52–2.65 (m, 1H), 3.31–3.48 (m, 5H), 3.78–3.97 (m, 1H), 5.25–5.50 (m, 1H), 6.99 (dt, J=9.1, 2.3 Hz, 2H), 7.34 (d, J=9.5 Hz, 1H), 7.43 (d, J=9.5 Hz, 1H), 7.77 (dt, J=9.1, 2.0 Hz, 2H) ppm. MS (DCl/NH3) m/z 424(M+H)+. Anal. Calculated for C17H18IN3O2.3.55HCl.1.80H2O: C, 34.90; H, 4.33; N, 7.18. Found: C, 34.53; H 3.95; N, 6.83.

Provenance & Evidence