Dimethylformamide → HCID 136380449, compound

Participants

Reaction Steps

A solution of 4-(naphth-1-yl)-3-thiosemicarbazide (38 mg, 0.175 mmol) and 4 carboxy-2-hydroxybenzaldehyde (35 mg, 0.211 mmol) in dimethylformamide (2 mL) was shaken with 4 Å molecular sieves for 2.5 h. PS-TsNHNH2 resin (50 mg, 0.147 mmol) was added, shaking continued for 1 h, then the resin filtered off. Water was added to the filtrate and the precipitated solid was filtered, washed (water, ether) and dried to give the title compound (52 mg, 81%) as a solid. MS (ES+) m/e 366 [M+H]+.

Provenance & Evidence