Iodine → 6-ethyl-5-iodo-1H-pyrimidin-4-one

Participants

Reaction Steps

50.8 g of iodine (0.20 mol) are introduced into 850 ml of acetic acid, and 14.8 g (0.21 mol) of chlorine are introduced at 30°-33° C., whereupon the iodine dissolves. 49.7 g (0.4 mol) of 4-hydroxy-6-ethylpyrimidine in solution in 150 ml of acetic acid are then added dropwise at 20° C., the crystalline end product separating out. Filtration with suction and recrystallisation from ethyl acetate yield 24.4 g of pure substance, m.p. 191°-192° C.

Provenance & Evidence