HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Piperazin-1-yl)benzo[d]oxazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(1,3-benzoxazol-2-yl)piperazine-1-carboxylate | HCID 40144297 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(Piperazin-1-yl)benzo[d]oxazole hydrochloride | HCID 66570214 | — |
Reaction Steps
10.8 mmol of 4-benzoxazol-2-yl-piperazine-1-carboxylic acid tert.-butyl ester were treated with 30 ml of a dioxane, saturated with gaseous hydrochloric acid. The heterogenous mixture was stirred at room temperature for 1 hour, before evaporation of the solvent. This yielded the title compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241761B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-40147853988043fa8b267e49eac810a4 |
| Source note | uspto-grants-2007_07 |