6-Nitro-2-piperazin-1-yl-1,3-benzothiazole → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(6-nitro-benzothiazol-2-yl)-piperazin-1-yl]-methanone

HRID 1294773노트

반응식

HRID 1294773 반응식
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[N+:18]([C:21]1[CH:35]=[CH:34][C:24]2[N:25]=[C:26]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)[S:27][C:23]=2[CH:22]=1)([O-:20])=[O:19]>O1CCCC1>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:31]1[CH2:32][CH2:33][N:28]([C:26]2[S:27][C:23]3[CH:22]=[C:21]([N+:18]([O-:20])=[O:19])[CH:35]=[CH:34][C:24]=3[N:25]=2)[CH2:29][CH2:30]1)=[O:9])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 7660126-Nitro-2-piperazin-1-yl-1,3-benzothiazoleHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

생성물 1

HCID 11504326(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(6-nitro-benzothiazol-2-yl)-piperazin-1-yl]-methanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared in analogy to example 1.1 b) from 2-Isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 6-Nitro-2-piperazin-1-yl-benzothiazole in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate), and the residue was then triturated in ether to yield the title compound as a yellow solid.

후처리

  1. customThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)
  2. customthe residue was then triturated in ether

출처 및 근거

ORD 기록
ord-76f310af37734b189db5bd011bf23d69
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241761B2

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