HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 6-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-6-ethoxybenzo[d]thiazole | HCID 350015 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole | HCID 28470888 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of 1.36 mmol 2-chloro-6-ethoxy-benzothiazole (CA=[79071-17-3]), 3.00 mmol of piperazine and 3.00 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241761B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-ed6dfc162bde45228b20d9d792863b02 |
| Source note | uspto-grants-2007_07 |