HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → [4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-isobutoxy-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Isobutoxy-5-methanesulfonyl-benzoic acid | HCID 23503110 | — |
| Reactant | 6-Chloro-2-piperazin-1-yl-quinoline hydrochloride | HCID 68896684 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-isobutoxy-5-methanesulfonyl-phenyl)-methanone | HCID 58906305 | — |
Reaction Steps
Prepared in analogy to example 1.1 (b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride and 2-isobutoxy-5-methanesulfonyl-benzoic acid (example 2.4) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241761B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-5096fe3454db46b1b49880a56495e49e |
| Source note | uspto-grants-2007_07 |