HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → [4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-diethylamino-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Diethylamino-5-methanesulfonyl-benzoic acid | HCID 57445276 | — |
| Reactant | 6-Chloro-2-piperazin-1-yl-quinoline hydrochloride | HCID 68896684 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-diethylamino-5-methanesulfonyl-phenyl)-methanone | HCID 58906315 | — |
Reaction Steps
Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 2-diethylamino-5-methanesulfonyl-benzoic acid (Example 2.5) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 501.4 (M+H+; 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241761B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-09caf0ee0f8e4683b562cc31d7697ea6 |
| Source note | uspto-grants-2007_07 |