HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 21036666, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | Di-tert-butyl diazene-1,2-dicarboxylate | HCID 6034084 | — |
| Reactant | 4-(4-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 11687740 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21036666 | HCID 21036666 | 62% |
Reaction Steps
A suspension of 4-(4-Hydroxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (3.11 g), 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester (3.51 g), and polymer supported triphenylphosphine (6.25 g; loading: 3 mmol/g) in DCM (100 mL) was treated with di-tert-butylazodicarboxylate (3.78 g). After 24 h, the resulting mixture was filtered, and the filtrate was evaporated. Chromatography of the residue (15–30% ethyl acetate/hexanes) gave the title compound as a white solid (3.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241778B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-e337683974784a50b03548861e879533 |
| Source note | uspto-grants-2007_07 |