Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Bromocyclopentane | HCID 8728 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(cyclopentyloxy)aniline | HCID 6484448 | — |
Reaction Steps
A mixture of 4-nitrophenol (63.7 g), bromocyclopentane (68.2 g), potassium carbonate (63.3 g) and DMF (300 mL) was heated at 80° C. for 24 hours. After cooling, it was diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate and concentrated. The residue was hydrogenated in ethanol using palladium(II) hydroxide as catalyst. The product with the molecular weight of 177.25 (C11H15NO) was obtained in this way; MS (ESI): 178 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07241787B2 |
|---|
| Source dataset | uspto-grants-2007_07 |
|---|
| ORD ID | ord-024e35d98a80490fa18226b209eecce1 |
|---|
| Source note | uspto-grants-2007_07 |
|---|
