Trifluoroacetic acid → HCID 178517285, compound

Participants

Reaction Steps

Trans-4-aminocyclohexanol was reacted by method B with CDI and (4-cyclopentyloxyphenyl)(2,2-diethoxyethyl)amine. The isolated crude product was mixed with DMF (2 ml) and TFA (2 ml) and left to stand for 12 hours. The reaction solution was diluted with water, and the mixture was extracted with ethyl acetate. The organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 342.44 (C20H26N2O3) was obtained in this way; MS (ESI): 343 ([M+H]+).

Provenance & Evidence