Sulfuric Acid → HCID 58760944, compound

Participants

Reaction Steps

A solution of 2-(4-chloro-phenyl)-1-(2-chloro-phenyl)-5-(2-methoxy-vinyl)-1H-imidazole-4-carboxylic acid ethyl ester I-5g (275 mg, 0.659 mmol) and H2SO4 (200 μl) in 5:1 THF/H2O (18 ml) was heated at 70° C. for 3 hours. The reaction mixture was cooled to room temperature and treated with 1M K2CO3 until the pH of the reaction mixture was ˜6. The aqueous solution was extracted with CH2Cl2 and the combined organic extracts were washed with sat'd aq. NaCl, dried, and concentrated in vacuo to give a mixture of the starting material and product (I-5h): +APCI MS (M+1) 403.3

Provenance & Evidence