反应详情

A solution of 2-(4-chloro-phenyl)-5-cyclopentylaminomethyl-1-(2-fluoro-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester I-5f (1.2 g, 2.68 mmol) in 1:2 1M KOH/THF was stirred at 55° C. for 17 hours. The reaction mixture was concentrated under vacuum and acidified to pH˜1 with concentrated hydrochloric acid. The residue was slurried in EtOH and filtered to remove KCI. The filtrate was concentrated under vaccum to give I-5k as an off-white solid (1.26 g, 97%): +APCI MS (M+1) 414.0.

1. concentrationThe reaction mixture was concentrated under vacuum
2. filtrationfiltered
3. customto remove KCI
4. concentrationThe filtrate was concentrated under vaccum