HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)benzoic acid | HCID 518002 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)- | HCID 11196047 | 99.5% |
Reaction Steps
Prepared according to Method A step A from 2-fluoro-3-trifluoromethylbenzoic acid (5.0 g, 24 mmol), N,O-dimethylhydroxylamine hydrochloride (3.4 g, 35 mmol), oxalyl chloride (2.18 mL, 25 mmol) and 6 mL of pyridine to give the title compound (6.0 g) as an oil. Used as is in the next prep
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241791B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-46e15f3064444a6f8e187fc7d7821cff |
| Source note | uspto-grants-2007_07 |