HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-chloro-2-fluoro-N-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 3-Chloro-2-fluorobenzoic acid | HCID 302931 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-chloro-2-fluoro-N-methoxy-N-methylbenzamide | HCID 11470003 | 88.2% |
Reaction Steps
Prepared according to Method A step A from 3-chloro-2-fluorobenzoic acid (3.0 g, 17.2 mmol), N,O-dimethylhydroxylamine hydrochloride (2.34 g, 24 mmol), oxalyl chloride (1.5 mL, 17.2 mmol) and 5 mL of pyridine to give the title compound (3.3 g) as an oil. Used as is in the next prep
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241791B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-67f2870a199f461aa0e6d7f48fcb8744 |
| Source note | uspto-grants-2007_07 |