3-chloro-2-fluoro-N-methoxy-N-methylbenzamide → (3-Chloro-2-fluorophenyl)-(4-methoxyphenyl)-methanone

HRID 1294861Notes

Reaction equation

HRID 1294861 reaction equation
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5](N(OC)C)=[O:6].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[CH:19][CH:18]=1>>[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:5]([C:20]2[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=2)=[O:6])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 114700033-chloro-2-fluoro-N-methoxy-N-methylbenzamideHCID 178491912HCID 178491912, compound

Product 1

HCID 11471075(3-Chloro-2-fluorophenyl)-(4-methoxyphenyl)-methanone

Procedure

Prepared according to Method A step B from 3-chloro-2-fluoro-N-methoxy-N-methylbenzamide (2.5 g, 11.5 mmol) and 4-methoxyphenylmagnesium bromide (25 mL, 0.5 M in THF) to give 0.3 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-46aa4a675ff540c284858f9ed3a40c3e
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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