HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2,3-difluoro-N-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 2,3-Difluorobenzoic acid | HCID 370590 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2,3-difluoro-N-methoxy-N-methylbenzamide | HCID 62661190 | 93.5% |
Reaction Steps
Prepared according to Method A step A from 2,3-difluorobenzoic acid (4.0 g, 25 mmol), N,O-dimethylhydroxylamine hydrochloride (3.4 g, 35 mmol), oxalyl chloride (2.2 mL, 25 mmol) and 6 mL of pyridine to give the title compound (4.7 g) as an oil. Used as is in the next preparation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241791B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-0d3e1950520446c4a33526cb36d3b4ab |
| Source note | uspto-grants-2007_07 |